Triamcinolone Base
triamcinolone
CAS: 124-94-7
Molecular Formula: C21H27FO6
Triamcinolone Base - Names and Identifiers
Triamcinolone Base - Physico-chemical Properties
| Molecular Formula | C21H27FO6 |
| Molar Mass | 394.43 |
| Density | 1.1703 (estimate) |
| Melting Point | 262-263°C(lit.) |
| Boling Point | 587.5±50.0 °C(Predicted) |
| Specific Rotation(α) | 69 º (c=2, DMF) |
| Flash Point | 309.1°C |
| Water Solubility | 79.99mg/L(25 ºC) |
| Solubility | DMF: soluble20 mg/mL |
| Vapor Presure | 3E-16mmHg at 25°C |
| Appearance | neat |
| Color | Crystals |
| Merck | 9595 |
| pKa | 11.57±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.617 |
| Use | Used as a hormone drug |
Triamcinolone Base - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 40 - Limited evidence of a carcinogenic effect |
| Safety Description | S22 - Do not breathe dust. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | TU3850000 |
| HS Code | 2937220000 |
| Toxicity | LD50 subcutaneous in mouse: > 4gm/kg |
Triamcinolone Base - Standard
Authoritative Data Verified Data
This product is 9a-fluoro-11B,16a,17a,21-tetrahydroxyprogestin -1, 4-dien-3, 20-dione. The content of C21H27FO6 shall be 97.0% ~ 102.0% calculated as dry product.
Last Update：2024-01-02 23:10:35
Triamcinolone Base - Trait
Authoritative Data Verified Data
- This product is white or white crystalline powder; Odorless.
- This product is soluble in N ,N-dimethylformamide, slightly soluble in methanol or ethanol, and almost insoluble in water or chloroform.
specific rotation
take this product, precision weighing, plus N,N-dimethylformamide dissolution and quantitative dilution of about 2mg per lml solution, according to the law (General 0621), the specific rotation was 65 ° to 72 °.
Last Update：2022-01-01 11:44:51
Triamcinolone Base - Differential diagnosis
Authoritative Data Verified Data
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 747).
Last Update：2022-01-01 11:44:51
Triamcinolone Base - Exam
Authoritative Data Verified Data
Related substances
take this product, add methanol to dissolve and dilute to make a solution containing about 0.5mg per 1ml as a test solution; Take 1ml for precision measurement and put it in a 100ml measuring flask, as a control solution, it was diluted to the scale with methanol and shaken. According to the chromatographic conditions under the content determination item, 20ul of the test solution and the control solution are respectively injected into the liquid chromatograph, and the chromatogram is recorded to 4.5 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, no more than 2 impurity peaks whose peak area is between 0.5 and 1.0 times the area of the main peak of the control solution, other single impurity peak area shall not be greater than 0.5 times (0.5%) of the main peak area of the control solution, and the sum of each impurity peak area shall not be greater than 2 times (2.0%) of the main peak area of the control solution. The peaks in the chromatogram of the test solution which were 0.02 times smaller than the main peak area of the control solution were ignored.
loss on drying
take this product and dry under reduced pressure at 60°C for 4 hours, and the weight loss shall not exceed 1.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residual liquid shall not exceed 0.2%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 11:44:52
Triamcinolone Base - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel bonded with eighteen alkyl silane was used as the filler; Acetonitrile-water (18:82) was used as the mobile phase; The detection wavelength was 238nm. The number of theoretical plates shall not be less than 6000 based on the calculation of quanxi Longfeng. The separation degree between quanxi Longfeng and adjacent impurity peaks shall meet the requirements.
assay
take this product, precision weighing, add methanol to dissolve and quantitatively dilute to make a solution containing about 0.16mg per lml, take 5ml for precision measurement, and put it in a 50ml measuring flask, dilute with methanol to the scale, shake, as a test solution, take the precision of 20u1 injection of human liquid chromatography, record the chromatogram; Another triamcinolone reference, the same method for determination. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 11:44:52
Triamcinolone Base - Category
Authoritative Data Verified Data
adrenocortical hormone drugs.
Last Update：2022-01-01 11:44:52
Triamcinolone Base - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:44:53
Triamcinolone Base - Triamcinolone Tablets
Authoritative Data Verified Data
This product contains Triamcinolone (C21H27F06) should be labeled amount of 90.0% ~ 110.0%.
trait
This product is white tablet.
identification
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- take an appropriate amount of the fine powder of this product (about 10mg of triamcinolone), put it in a 50ml measuring flask, add an appropriate amount of methanol, shake to dissolve triamcinolone, and dilute it with methanol to the scale, shake well, filter, Take 5ml of the filtrate, put it in a 50ml measuring flask, dilute it with methanol to the scale, shake well, and measure it by UV-Vis spectrophotometry (General rule 0401), there is an absorption maximum at a wavelength of 238nm.
examination
- Content uniformity take 1 tablet of this product, put it in a 25ml measuring flask, add an appropriate amount of methanol, ultrasonic dissolve triamcinolone, let it cool, dilute to the scale with methanol, shake well, filter, precisely take 5ml of continued filtrate, put it in a 50ml measuring flask, dilute it to the scale with methanol, shake it well, measure it according to the method under the content determination item, calculate the content, and the content shall be in accordance with the regulations (General rule 0941)..
- dissolution the dissolution of this product was determined according to the dissolution and release determination method (General rule 0931, the first method), and the hydrochloric acid solution (9-1000) was used as the dissolution medium, and the rotation speed was 100 rpm, according to the law, after 45 minutes, the solution was filtered, and the filtrate was taken, and the absorbance was measured at a wavelength of 238mn by ultraviolet-visible spectrophotometry (General 0401). In addition, accurately weigh about 16mg of triamcinolone reference product, put it in a 200ml measuring flask, add 20ml of methanol, shake to dissolve it, dilute it to scale with dissolution medium, and shake well, 5ml was accurately measured, placed in a 50ml measuring flask, diluted to the scale with dissolution medium, shaken, measured by the same method, and the dissolution amount of each tablet was calculated. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (about equivalent to 16mg triamcinolone), put it in a 100ml measuring flask, add an appropriate amount of methanol, ultrasonic dissolution of triamcinolone, let it cool, dilute to scale with methanol, shake well, filter, accurately take 5ml filtrate, put it in 50ml measuring flask, dilute to scale with methanol, shake, as a test solution, according to triamcinolone content determination method under the item, that is obtained.
category
The same as triamcinolone.
specification
4mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:44:53
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Product Name: Triamcinolone Request for quotation
CAS: 124-94-7
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CAS: 124-94-7
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Email: sales@hbmojin.com
Mobile: 0086 15028179902
QQ: 2632046152
Wechat: 0086 15028179902
WhatsApp: 0086 15028179902
Multiple SpecificationsSpot supply
Product Name: Triamcinolone (Standard) Visit Supplier Webpage Request for quotationCAS: 124-94-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Triamcinolone Visit Supplier Webpage Request for quotationCAS: 124-94-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
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Product Name: Triamcinolone Visit Supplier Webpage Request for quotationCAS: 124-94-7
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View History
Triamcinolone Base
NSC51618
5-Chloro-2-Methyl-4-Isothiazolin-3-One
2-Methyl-5-nitropyridin-3-amine
4-(2-PIPERIDINOETHOXY)BENZOIC ACID HCL
NSC51618
5-Chloro-2-Methyl-4-Isothiazolin-3-One
2-Methyl-5-nitropyridin-3-amine
4-(2-PIPERIDINOETHOXY)BENZOIC ACID HCL